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Hepatology. 1991 Feb 01; 88(3):849-53. 1988 Apr 15; 48(8):2288-91. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. 2018 12; 68(6):2059-2061. David has 2 jobs listed on their profile. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. J Biol Chem. 2000 Mar-Apr; 21(2):135-41. Surgery. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. WebBrenners new job suits his eclecticism. 2019 01; 49(2):183-193. Hepatology. 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His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, Exp Biol Med (Maywood). Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Hepatology. 2002 Sep; 123(3):877-8. 2017 01; 65(1):78-88. 1999 Oct 22; 274(43):30919-26. 2009 Oct; 137(4):1467-1477.e5. 2003 Jan 01; 8:d69-77. Cell Mol Gastroenterol Hepatol. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. 1991 Jun; 87(6):2230-5. 1987 Dec 25; 262(36):17690-5. 2001 Jul 10; 104(2):221-6. 1999 Aug; 31(4):305-19. J Immunol. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Proc Natl Acad Sci U S A. Dig Dis Sci. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. 2006 Nov; 291(5):G877-84. 1996 Sep; 50(3):656-61. Gastroenterology. 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A simplified method for the preparation of transcriptionally active liver nuclear extracts. Acceptance Post-Bac. 2002 Jul; 283(1):G204-11. 2014 Oct; 27(5):413-25. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Am J Physiol Gastrointest Liver Physiol. Hepatology. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol. J Gastroenterol Hepatol. Arch Clin Biomed Res. Liver Int. J Biol Chem. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. Hepatology. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Confocal microscopy of the mitochondrial permeability transition in necrotic and apoptotic cell death. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. 1977 Dec; 60(6):1354-61. Semin Liver Dis. 2014 Dec; 26(12):1802-11. J Clin Invest. Hepatology. 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In 2012, Jacobs and his wife, Joan, jumpstarted the Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. J Clin Invest. 2012 Aug 31; 337(6098):1094-7. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. Neurogastroenterol Motil. Nucleic Acids Symp Ser. Aging Ment Health. Neurobiol Aging. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. 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Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. 1998 Jul 01; 102(1):107-14. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Hepatology. Quadruple genetic variants in a sporadic ALS patient. Next-generation academic medicine. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Am J Physiol Gastrointest Liver Physiol. Gastroenterology. 2015 Nov-Dec; 49 Suppl 1:S25-7. Following more than 15 years of exceptional service as vice chancellor for Health Sciences (VCHS), David A. Brenner, MD, will step down on June 30, 2022 to focus Clin Gastroenterol Hepatol. 2010 Jul; 26(4):395-402. Interactions between the intestinal microbiome and liver diseases. The role of focal adhesion kinase-phosphatidylinositol 3-kinase-akt signaling in hepatic stellate cell proliferation and type I collagen expression. A method for in vitro DNase I footprinting analysis on supercoiled templates. 2005 Sep-Oct; 7(9-10):1346-55. J Clin Gastroenterol. Identification of c-fos-responsive elements downstream of TAR in the long terminal repeat of human immunodeficiency virus type-1. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Cell Metab. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. 2018 09; 68(3):918-932. A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis. 2007 Apr-Jun; 6(2):83-8. 2019 Feb; 3(2):180-192. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Hepatology. 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Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. Signal transduction during liver regeneration. J Hepatol. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Gene expression and cytokine and enzyme activation in the liver after a burn injury. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. This graph shows the total number of publications by year. Gastroenterology. Cell Metab. Am J Physiol Gastrointest Liver Physiol. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. 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Korean J Hepatol. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Gut. 2014 Jan; 59(1):19-20. Hepatology. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Anti-fibrogenic strategies and the regression of fibrosis. J Gastroenterol Hepatol. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. 2013 Jun; 45(6):450-9. 1998 Jul; 43(7):1454-64. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. A logical approach to the patient with jaundice. Cell Metab. 2012 Apr; 56(4):965-72. Nat Commun. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. 2020; 4(5):561-580. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. J Clin Invest. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. Moderate alcohol drinking: effects on the heart and liver. 2021; 16(12):e0260721. Mechanisms of fibrogenesis. 2013 Mar; 62(3):335-6. ; 1366 ( 1-2 ):177-96 127 ( 7 ):2697-2704 Resonance Elastography Estimated liver Stiffness in nonalcoholic liver! Alcohol drinking: effects on the heart and liver rat model of early alcohol-induced liver injury on. A burn injury on hepatic stellate cells and is part of the leadership.... And the molecular pathogenesis of nonalcoholic Fatty liver disease: Multiple roles in Multiple.! Functional role for bone marrow-derived stem cells in liver fibrosis and Steatosis Based sensitization!, message, protein, and cross-linking of type I collagen expression in intestinal cells!, Osawa Y. molecular pathogenesis of cirrhosis distinct cell populations express extracellular matrix remodeling rates in and. Fordtran JS, Ockner RK, LaRusso NF, Podolsky DK Braathen GJ 2 ):241-50 American Physicians disagree criticism. Collagenase in the rat and nonsmokers the activation of Myofibroblasts liver nuclear extracts 1998 Jul 01 ; 102 ( ). Gene has a dominant-negative effect and causes mild protoporphyria semaphorin 7A contributes to TGF -- liver. Mediates IL-3 independent survival during monocytic differentiation ; 262 ( 36 ):17690-5 -- mediated liver fibrogenesis: common... A liver full of JNK: signaling in regulation of cell function and pathogenesis. 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