MeSH PMC Two pathologists interpreted the FISH results using an Olympus fluorescence microscope equipped with 100 objective lens and orange/ green/4, 6-diamid-ino-2-phenylindole filters. Polyclonal lymphoid proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic. 1998;18:38792. His IPI score was 2(low to intermediate risk group). This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. Acta Ophthalmol. All gene rearrangement studies were performed according to the standard assay procedure, and the results were interpreted according to the assay instructions as described previously [10]. This study was supported by grants from CAMS Initiative for Innovative Medicine (CAMS-I2M) (2016-I2M-1-002). FOIA Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. The complaints due to severe HBT were noisy respiration, hoarseness, throat clearing, dry cough, globus pharyngeus, and nasal voice. Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. Lymphoid hyperplasia is a rapid increase in the number of normal cells (called lymphocytes) that are contained in lymph nodes. [36] showed that patients with DLBCL located on Waldeyers ring (base of the tongue) often have a better prognosis than nodal DLBCL patients. 2013;91 Thesis 5:127. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. 2005;23:2797804. It tends to present as a unilateral, painless, slow-growing, nonulcerated mass. [citation needed], Sinus hyperplasia is the preferential stimulation of the histiocytic (tissues macrophage) compartment. One case presented as multiple deep ulcers. The objective of the present study was to identify severe HBT cases and their symptoms and to correlate them with the presence of pharyngolaryngeal signs and esophageal symptoms of gastroesophageal reflux (GER) in patients seen at a laryngology clinic. 1997;36:41320. Xinyu Ren and Yin Cheng contributed equally to this work. Cutaneous lymphoid hyperplasia is generally not malignant, but in rare cases an association has been observed. Virchows Arch. 88, no. In the literature, the patients with peripheral T cell lymphoma of the tongue base were middle aged with no obvious differences in gender distribution. The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. 1998;112:9914. Except in one case of four, all of our patients were alive through follow-up. Mamede RC, De Mello-Filho FV, Vigrio LC, Dantas RO. Co. Ltd., China. In contrast, they did not express CD3, CD10, CD23, or TdT. Article Lopez-Guillermo A, Colomo L, Jimenez M, Bosch F, Villamor N, Arenillas L, Muntanola A, Montoto S, Gine E, Colomer D, Bea S, Campo E, Montserrat E. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. 4th ed. Patricia Uherova et al. This report adds valuable knowledge to the possible virus infection status of tongue NHL, due to its rare occurrence. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. Guastafierro S, Falcone U, Celentano M, Cappabianca S, Giudice A, Colella G. Primary mantle-cell non-Hodgkin's lymphoma of the tongue. https://doi.org/10.1017/s0022215100142288. Int J Oral Maxillofac Surg. 1. The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. 2004;103:27582. Image courtesy of James J. Sciubba, DMD, PhD. The possible reason was that the patient had several high risk factors, such as old age (in his nineties), positivity for c-Myc and P53, and co-expression of c-Myc (50%), Bcl-2 and Bcl-6 [38]. All DLBCL cases were positive for CD20, Mum1,Bcl-2 and Bcl-6 and negative for CD5. Unauthorized use of these marks is strictly prohibited. 96, no. The role of EBV in the pathogenesis of diffuse large B cell lymphoma. doi: 10.1148/radiology.144.4.7111732. At this power, within the germinal center are paler-staining cells that are tingible body macrophages involved in the removal of apoptotic or degenerated lymphocytes. Ren, X., Cheng, Y., Wu, S. et al. Viral infections, such as HIV or hepatitis C virus (HCV), can also develop in immunocompromised patients. https://doi.org/10.4149/BLL_2017_116. 1979 Sep;30(5):485-8. doi: 10.1016/s0009-9260(79)80176-2. A finding indicating enlargement of the tongue. Diagn Pathol 15, 30 (2020). A case of benign. Her chemotherapy regimen was changed to GDP. d. Tumour cells diffusely expressed CD3 (200x). 2017;118:6028. XS and QL did the HPV ISH. Cut-off values were set as previously described [9]. Article In addition, patients may notice irregularities on their own, thereby bringing the appearance to the attention of their dentists or hygienists. The clinical features of tongue base involvement by NHL are not specific [17]. Immunohistochemically, the atypical lymphoid cells were positive for CD20, CD79a, PAX-5, CD5, CyclinD1 protein, and Ki-67 antigen (labelling 25%). World J Gastroenterol. Effect of gastroesophageal reflux on hypertrophy of the base of the tongue. From 2010 to 2017, a total of 2088 cases of lymphoma were diagnosed and treated at PUMCH. By that time, and at one week after discharge, the pharynx appeared within normal limits. Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z, Farinha P, Smith LM, et al. There is usually a bilateral . [3] Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles). Lee YY, Van Tassel P, Nauert C, North LB, Jing BS. In addition, an understanding of these diseases will allow the development of new targeted therapies for these aggressive lymphomas. Paraffin sections were prepared according to the ThermoBrite Elite Automated FISH slide prep system manufacturers protocol. 2). HPV is considered to be associated with the occurrence of oropharyngeal squamous cell carcinoma [8], therefore, we detected the infection status of the the two viruses in lymphoma of the base of the tongue. Sun J, Zhang J, Ling Q, Luo Y, Wu S, Liang Z, Zhong D, Zeng X. In the literature, findings of RLH are well-documented. The follicles are cytologically polymorphous, are often polarized, and vary in size and shape. Bone marrow involvement was identified at relapse. https://doi.org/10.1053/ajot.2000.8382. 4 Metrics Downloaded 279 times PDF download Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications. These lymphoid tissues are controlled by specialized cells that arm themselves to attack and destroy foreign invaderssuch as bacteria, fungi, or virusesthrough phagocytosis or the production of antibodies. This is slightly different from the cases reported by Owosho AA et al. Jrvenp P, Ilmarinen T, Geneid A, Pietarinen P, Kinnari TJ, Rihkanen H, Ruohoalho J, Markkanen-Leppnen M, Bck L, Arkkila P, Aaltonen LM. CAS Almost all cancers in the base of the tongue are squamous cell carcinomas, which form in the thin, flat cells that line the larynx. Mucosa-associated lymphoid tissue lymphoma of the lingual tonsil. The diagnosis of FLH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and histopathology. 2023 BioMed Central Ltd unless otherwise stated. Despite some degree of resolution, lingual and palatine tonsillectomy was performed using electrocautery 7 days after tracheotomy. Then he looked down my throat through my nose. Positive nucleolus staining was used to identify Bcl-6, mum-1, CyclinD1, SOX11 and Ki-67. HPV RNA ISH all negative. https://doi.org/10.1111/aos.12189. These tissues act as your body's first line of defense against infections. There were no c-Myc rearrangements, so there were no double or triple hit B cell lymphomas in these cases (Table3). Benign Lymphoid Hyperplasia of the Tongue Base Causing Upper Airway Obstruction Severe benign lymphoid hyperplasia (LH) is unusual in the head and neck region, but the diagnosis of LH is of clinical importance as it may be confused with malignant lymphoma, both on clinical examination and pathologically. In our case, the late stage of disease, the morphologically blastic variant [44], and involvement of neck lymph nodes were all factors that contributed to poor prognosis of this patient. I am taking medicine nd it is reducing but its been 3 weeks now? statement and All 7 lymphomas were localized at the base of the tongue. d. Tumour cells were positive for C-myc (200 x). PubMed This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. The biopsy showed recurrence, with bone marrow involvement. Leuk Res. Six of the cases exhibited tongue base masses with smooth surface membranes. Increasingly, cancers at the base of the tongue are . M. Samoszuk, E. Ramzi, and J. Ravel, Disseminated persistent lymphoid hyperplasia containing Epstein-Barr virus and clonal rearrangements of DNA, Diagnostic Molecular Pathology, vol. https://doi.org/10.1016/j.anndiagpath.2005.09.020. Primary diffuse large B-cell lymphoma of the ovary is of a germinal Centre B-cell-like phenotype. Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K, Nakamura S. Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified. Primary non-Hodgkin lymphoma of the tongue base: the clinicopathology of seven cases and evaluation of HPV and EBV status. Survival data on PTCL are limited due to the short follow-up time in the literature. Spontaneous regression has also been reported. Follicular lymphoid hyperplasia (FLH) is a benign lymphoproliferative process of unknown etiology, uncommon in the head and neck region. The exceptional case here was a 45-year-old male patient with diffuse large B cell lymphoma who presented with only deep painful mouth ulcers and general symptoms, including sore throat, choking when drinking water, and difficulty swallowing. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. https://doi.org/10.1159/000278291. PubMed Google Scholar. Her IPI score was 3 (high risk group). 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